Mechanisms underlying heart failure
نویسندگان
چکیده
منابع مشابه
Metabolic mechanisms in heart failure.
Although neurohumoral antagonism has successfully reduced heart failure morbidity and mortality, the residual disability and death rate remains unacceptably high. Though abnormalities of myocardial metabolism are associated with heart failure, recent data suggest that heart failure may itself promote metabolic changes such as insulin resistance, in part through neurohumoral activation. A detrim...
متن کاملMechanisms underlying improvements in ejection fraction with carvedilol in heart failure.
BACKGROUND Reductions in heart rate (HR) with beta-blocker therapy have been associated with improvements in ejection fraction (EF). However, the relative contributions of HR reduction, positive inotropism, afterload reduction, and reverse remodeling to improvements in EF are unknown. METHODS AND RESULTS Twenty-nine patients (63+/-12 years old) with New York Heart Association class II-III hea...
متن کاملMolecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure.
Heart failure (HF) is characterized by marked prolongation of action potential duration and reduction in cellular repolarization reserve. These changes are caused in large part by HF-induced K(+) current downregulation. Molecular mechanisms underlying these changes remain unclear. We determined whether downregulation of K(+) currents in a canine model of tachycardia-induced HF is caused by alte...
متن کاملMechanisms of diastolic dysfunction in heart failure.
Abnormalities of diastole are common to most forms of congestive heart failure (HF). Diastolic function is broadly defined as the ability of the heart to fill adequately and at normal pressure to charge the ventricular pump for each subsequent contraction. It is determined by both active and passive processes occurring at the level of the myocyte, extracellular matrix, and left ventricular cham...
متن کاملMechanisms of Wasting in Heart Failure
It has been established for centuries that body wasting and changes in body composition play important roles in patients with chronic diseases. This is also true for patients with heart failure (HF).1 For clinicians not actively involved in this area of research, however, it may be difficult to decipher the complex and sometimes confusing terminology used in this context. Cachexia, body wasting...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Disease Mechanisms
سال: 2010
ISSN: 1740-6765
DOI: 10.1016/j.ddmec.2010.10.001